Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

Scientists at Utrecht University have developed a unique fluorescent sensor that lets us watch DNA damage and repair happen live inside living cells and organisms. Instead of relying on still ...

Scientists have created a live-cell DNA sensor that reveals how damage appears and disappears inside living cells, capturing the entire repair sequence as it unfolds. Instead of freezing cells at ...

Faithful DNA replication is essential for cell survival and genome stability. However, DNA replication faces continual challenges from DNA damage, as well as intrinsic and extrinsic stressors. For ...

GRB2 is an intracellular adapter protein essential for cell proliferation that consists of a central SH2 domain flanked by two SH3 domains 1,2,3,4,5. Classically its SH3 domains direct complex ...