NFL Week 16 Picks & Predictions
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ESPN insiders fuel Chiefs trade rumors as Kansas City faces a tough secondary decision amid cap pressure and an uncertain 2026 outlook.
In Week 1, the Seahawks lost 17-13 to the 49ers, and in that game, both Darnold and Jaxon Smith-Njigba fumbled the ball away in the fourth quarter. In Week 5, the Seahawks lost 38-35 because their defense couldn't stop Baker Mayfield, who threw for 379 yards. In Week 11, the Seahawks lost to the Rams because Darnold threw four interceptions.
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Early Week 15 bets: Underdog Patriots to top Bills, Lions to cover in shootout with Rams among picks
Among them are the Detroit Lions visiting the Los Angeles Rams (-6, 55.5), with both teams coming off big wins, the New England Patriots hosting the Buffalo Bills (-1.5, 50.5) in a key AFC East clash and the NFC North-leading Green Bay Packers (-2.5, 43.5) hitting the road to face the AFC West front-running Denver Broncos.
There are some juicy matchups this weekend, many with playoff implications for the league's top teams. But no one is more desperate than Kansas City.
See who's in and who's out for the Week 16 matchup between the Denver Broncos and Jacksonville Jaguars on December 21, 2025.
Let's update our NFL Power Rankings ahead of Week 16. We also looked at players who could get contract extensions this offseason.