Predictions, picks and odds for NFL Week 16 game
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The Week 12 NFL schedule is headlined by the ever-continuing saga of the Kansas City Chiefs against the AFC South-leading Indianapolis Colts on Nov. 23. Kansas City is 5-5 after losing on a last-second field goal at Denver and returns home in need of a run.
Sam Farmer makes his picks and score predictions for Week 12 of the NFL season, with Patrick Mahomes and the Chiefs winning at home over the Colts.
The NFL is all about parity, and Week 16 will offer some high-powered matchups that'll continue to create separation in several key divisions around the league. Last week, the Denver Broncos (12-2) and Los Angeles Rams (11-3) became the first two teams to clinch a playoff spot this season.
The Miami Dolphins have a chance to even their record at 7-7 with a win against the Pittsburgh Steelers. The Denver Broncos are ranked number one in the NFL Power Rankings after Week 15 with a 12-2 record. The Los Angeles Rams and Seattle Seahawks follow the Broncos in the power rankings.
NFL RedZone — an around-the-horn live highlight show demonstrating all the action on NFL Sunday — is back for Week 15 of the 2025 season.
Here’s a look at how various national experts rated the Broncos in their power rankings entering Week 16:
In Week 1, the Seahawks lost 17-13 to the 49ers, and in that game, both Darnold and Jaxon Smith-Njigba fumbled the ball away in the fourth quarter. In Week 5, the Seahawks lost 38-35 because their defense couldn't stop Baker Mayfield, who threw for 379 yards. In Week 11, the Seahawks lost to the Rams because Darnold threw four interceptions.
Where do the Titans currently pick in the 2026 NFL Draft?