Nature

ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression

Pyruvate generated from glucose metabolism is a key nutrient for cell metabolism critical for maintaining energy production, cell homeostasis and biological processes 1,2. It sits at crossroads for ...
Nature

Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation

Activation of brown adipose tissue (BAT) contributes to total body energy expenditure through energy dissipation as heat. Activated BAT increases the clearance of lipids and glucose from the ...
Mena FN

6-PPDQ Disrupts Citric Acid Cycle In C. Elegans Via Reduced Acetyl Coa And Pyruvate

HOW Does 6-PPDQ disrupts the citric acid cycle in caenorhabditis elegans. FAYETTEVILLE, GA, UNITED STATES, July 2, 2025 /EINPresswire / -- Researchers explore how 6-PPD quinone (6-PPDQ), an ...